SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB38235

Signal sequence   MNFSTVFQAIIAVLGLTTVTALA

Length  23

Organism  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

UniProt ID  P40520,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB38235.cif

Structure  SPKB38235.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2381.85604

Aliphatic index  140

Isoelectric point  6.099999998

Charge (pH=7)   -0.002015701

Topological polar surface area  890.85

Aromaticity  0.086956522

Average rotatable bonds  3.260869565

Number of hydrogen bond donors  31

Number of hydrogen bond acceptors  32

X logP energy  -7.1317

Hydropathy 



Literature Information


Title  Biological factors and statistical limitations prevent detection of most noncanonical proteins by mass spectrometry.

DOI  10.1371/journal.pbio.3002409,

Publication Year  2023

PubMed ID  38048358,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.