SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB33980

Signal sequence   LTGHLCCMMIWWQATQ

Length  16

Organism  Hadronyche infensa (Fraser island funnel-web spider) (Atrax infensus)

UniProt ID  A0A1D0BRC1,

Motif  <1..16



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB33980.cif

Structure  SPKB33980.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1922.32604

Aliphatic index  79.375

Isoelectric point  7.253156577

Charge (pH=7)   -0.035056042

Topological polar surface area  686.72

Aromaticity  0.125

Average rotatable bonds  3.6875

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  26

X logP energy  -3.4679

Hydropathy 



Literature Information


Title  Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene.

DOI  10.1073/pnas.1914536117,

Publication Year  2020

PubMed ID  32398368,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.