SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB26927

Signal sequence   MARKTVAAALALVAGAAVAVTGNAPAQA

Length  28

Organism  Streptomyces violaceus (Streptomyces venezuelae)

UniProt ID  P22998,

Motif  1..28



Activity Information


Pathway  Sec

Natural/Artificial  Natural

Subcellular location  Extracellular environment

Secretion efficiency  mTNF: 8mg/L

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB26927.cif

Structure  SPKB26927.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2565.02944

Aliphatic index  112.142857142857

Isoelectric point  11.6517756665126

Charge (pH=7)   1.99768595424049

Topological polar surface area  1054.79

Aromaticity  0

Average rotatable bonds  2.85714285714286

Number of hydrogen bond donors  36

Number of hydrogen bond acceptors  36

X logP energy  -12.74023

Hydropathy 



Literature Information


Title  Influence of charge variation in the Streptomyces venezuelae alpha-amylase signal peptide on heterologous protein production by Streptomyces lividans

DOI  10.1007/s002530051193,

Publication Year  1998

PubMed ID  9615485,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.