Peptide-Information

General Information

SPKB ID SPKB26469

Signal sequence MPKLEMMLLVLLILPLPYFDAAGG

Length 24

Organism Conus fergusoni (Ferguson's cone)

UniProt ID P0DQX1,

Motif 1..24

Activity Information

Pathway SRP-dependent

Natural/Artificial Natural

Subcellular location ER

Secretion efficiency NA

Type Sec/SPI

Structure Information

PDB ID NA,

Predicted Structure ID SPKB26469.cif

Structure SPKB26469.cif

Very high (pLDDT > 90)

Confident (90 > pLDDT > 70)

Low (70 > pLDDT > 50)

Very low (pLDDT < 50)

Loading PAE…

Expected Position Error (Ångströms)

Physicochemical Information

Molecular weight 2646.34314

Aliphatic index 150.4166667

Isoelectric point 4.184406685

Charge (pH=7) -1.000939542

Topological polar surface area 827.1

Aromaticity 0.083333333

Average rotatable bonds 3.458333333

Number of hydrogen bond donors 26

Number of hydrogen bond acceptors 32

X logP energy 1.3135

Hydropathy

Literature Information

Title A Novel Dimeric Conotoxin, FrXXA, from the Vermivorous Cone Snail Conus fergusoni, of the Eastern Pacific, Inhibits Nicotinic Acetylcholine Receptors.

DOI 10.3390/toxins14080510,

Publication Year 2022

PubMed ID 35893752,

Patent ID NA,