SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB25146

Signal sequence   MKTIIAAIFLGILMHAFA

Length  18

Organism  Dipetalogaster maximus (Blood-sucking bug)

UniProt ID  G3CJS0,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB25146.cif

Structure  SPKB25146.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1961.49744

Aliphatic index  152.2222222

Isoelectric point  9.702001779

Charge (pH=7)   1.088598356

Topological polar surface area  632.95

Aromaticity  0.111111111

Average rotatable bonds  3.555555556

Number of hydrogen bond donors  22

Number of hydrogen bond acceptors  24

X logP energy  0.0947

Hydropathy 



Literature Information


Title  Dipetalodipin, a novel multifunctional salivary lipocalin that inhibits platelet aggregation, vasoconstriction, and angiogenesis through unique binding specificity for TXA2, PGF2alpha, and 15(S)-HETE.

DOI  10.1074/jbc.M110.152835,

Publication Year  2010

PubMed ID  20889972,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.