SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB22575

Signal sequence   MCFATRRWFYLHLGCMMLINLVNA

Length  24

Organism  Homo sapiens (Human)

UniProt ID  A0A1B0GVD1,

Motif  1..24



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB22575.cif

Structure  SPKB22575.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2904.58094

Aliphatic index  101.6666667

Isoelectric point  8.806798886

Charge (pH=7)   1.964086922

Topological polar surface area  1027.53

Aromaticity  0.166666667

Average rotatable bonds  3.833333333

Number of hydrogen bond donors  39

Number of hydrogen bond acceptors  37

X logP energy  -3.99306

Hydropathy 



Literature Information


Title  A Pilot Screen of a Novel Peptide Hormone Library Identified Candidate GPR83 Ligands.

DOI  10.1177/2472555220934807,

Publication Year  2020

PubMed ID  32713278,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.