SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB22574

Signal sequence   MADPGNRGGIHRPLSFTCSLLIVGMCCVSPFFC

Length  33

Organism  Homo sapiens (Human)

UniProt ID  A0A1B0GTK4,

Motif  1..33



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB22574.cif

Structure  SPKB22574.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3530.23234

Aliphatic index  79.6969697

Isoelectric point  7.935855598

Charge (pH=7)   0.841434388

Topological polar surface area  1281.94

Aromaticity  0.090909091

Average rotatable bonds  3.272727273

Number of hydrogen bond donors  48

Number of hydrogen bond acceptors  49

X logP energy  -12.32786

Hydropathy 



Literature Information


Title  A Pilot Screen of a Novel Peptide Hormone Library Identified Candidate GPR83 Ligands.

DOI  10.1177/2472555220934807,

Publication Year  2020

PubMed ID  32713278,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.