SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB16699

Signal sequence   MIKVTIFLLLSIFSFNLYG

Length  19

Organism  Plasmodium falciparum (isolate 3D7)

UniProt ID  C0H571,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  Host cell membrane

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  7KIY,

Predicted Structure ID  SPKB16699.cif

Structure  SPKB16699.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2219.75334

Aliphatic index  158.9473684

Isoelectric point  9.298300651

Charge (pH=7)   0.996838851

Topological polar surface area  737.15

Aromaticity  0.210526316

Average rotatable bonds  3.789473684

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  27

X logP energy  -0.4659

Hydropathy 



Literature Information


Title  The Plasmodium falciparum RhopH2 promoter and first 24 amino acids are sufficient to target proteins to the rhoptries.

DOI  10.1016/j.parint.2006.11.001,

Publication Year  2007

PubMed ID  17175193,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.