SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB13810

Signal sequence   MWIKSVCLFATIAGCLGQ

Length  18

Organism  Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)

UniProt ID  Q8ISB6,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB13810.cif

Structure  SPKB13810.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1941.39494

Aliphatic index  113.8888889

Isoelectric point  8.229691165

Charge (pH=7)   0.873739834

Topological polar surface area  683.38

Aromaticity  0.111111111

Average rotatable bonds  3.444444444

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  26

X logP energy  -3.8701

Hydropathy 



Literature Information


Title  Beta-1,3-glucan recognition protein-2 (betaGRP-2)from Manduca sexta; an acute-phase protein that binds beta-1,3-glucan and lipoteichoic acid to aggregate fungi and bacteria and stimulate prophenoloxidase activation.

DOI  10.1016/j.ibmb.2003.09.006,

Publication Year  2004

PubMed ID  14976985,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.