General Information
SPKB ID SPKB12397
Signal sequence MARARPSVAGGGVAAPPERAGPGRPRRSRTGHHCDPECPGLRAAPRTPGPGAGRRAAKLRPGRGWWALLLLQLHLLRALAQDDVAPYFKTEPGLPQIHLEGNRLVLTCLAEGSWPLEFKWIRNDSELTTYSSEYKYIIPSLQKLDAGFYRCVVRNRMGALLQRKSEIQVAYMGNFMDTDQRKTVSQGHAALLNLLPIVSCPQPQVTWFREGHKIIPSSRIAITLENQLVILATTASDAGAYYVQAVNEKNGENKTSPFIHLSVARDTGTHEAMAPIIVVAPGNRSVVAGSSETTLECIANARPVEELSVHWKRNGVRLTSGLHSYGRRLTITNPTSADTGMYVCEATLRGSTFEPARARAFLSIIEPPYFTAEPESRILGEVEETMDIPCRAMGVPLPTLQWYKDAVPLSKLQNPRYKVLPSGGLHIQKLSPEDSGIFQCFASNEGGEVQTHTYLDVTNIAPAFTQRPVDTTVTDGMTAVLRCEVSGAPKPAITWKRGNHILASGSVRIPRFMLLESGGLRIAPVFIQDAGNYTCYAANTEASVNASAMLTVWNRTSIVHPPEDRVVIKGTTATLCCGATHDPRTSLRYVWKKDNVVITASSSSRIVVEKDGSLVISQTWSGDIGDYTCEIISEGGSDSRTARLEVIELPHPPQNLLASLSPARSHSVTLSWVRPFDGNSPVLYYIVQVSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNQVGKGQYSTETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEHQQRNISSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQAEAVNSTTVHFLWNPPPQQFINGINQGYKLLAWPADAPETVTVVTIAPDFHGIHHGYITNLKKFTAYFTSVLCFTTPGDGPPSSPQLVWTHEDKPGAVGHLSFTEILDTSLKVSWQEPLERNGIIMGYQISWEVYGRNDSRLTHTLNSTMHEYKIQGLSSLTTYTIDVAALTAAGVGVTTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTAICRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMRQVNIVGPSPFSQSSRVIQTLQAPPDVAPTSLTVRTASETSLRLRWVPLPDSQYNGNPESVGYRVKYWRSDQPSSALAQVVSDRLERELTIEELEEWTEYELRMQAFNAIGAGPWSELVRGRTRESVPSAAPENVSAEAVSSTQILLTWASVPEQDQNGLILGYKVLYCAKDLDPEPRSHVVRGNHTQSALLAGLRKFVVYELQVLAFTRIGNGVPSSPLILERTKDDTPGPPVRLVFPEVRLTAVRIVWQPPEEPNGVILGYQIAYRLASGSPHTFTTVEVGATVRQFTATELAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTVQVRELPGGEWQTYSSSISHEATACAVERLRPFTSYKLRLKATNDIGDSDFSAETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELESETGMSPEPKTLKSPSALRAELTAQSSFKTVNSSSSLTTYELTHLKKYRRYEVIMTAYNIIGESPASVPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKVYYWEADSRNETEKMKVLFLPEPVVKIKDLTSHTKYLISISAFNAAGDGPKSDPCQGRTHQAAPGPPSFLAFSEITSTTLNVSWGEPSAANGILQGYRVVYEPLAPVQGVSKVVTVDVKGNWQRWLKVRDLTKGVTYFFRVQARTIAYGPELQANVTAGPAEGSPGSPRNVLVTKSASELTLQWTEGNAGTTPTTGYVIEARPSDEGLWDMFAKDIPRSATSYTVDLDKLRQGVTYEFRVVAVNKAGFGEPSRPSIAVSAQAEAPFYEEWWFLLVMALSSLLLILLVVFVLVLHGQSKKYKSCSTGKGISNMEETVTLDNGGFAALELNSRHLNVKSTFSKKNGTRSPPRPSPGGLHYSDEDICNKYNGAVLTESVNLKEKSVDGSESEASDSDYEEALPKHSFVNHYMSDPTYYNSWKRRPPAAAPHRYEAVAGAEAGPHLHTVITTQSAGGVYTPAGPGARAPLTGFSSFV
Length 100
Organism Mus musculus (Mouse)
UniProt ID Q3UH53,
Motif 1..NA
Activity Information
Pathway SRP-dependent
Natural/Artificial Natural
Subcellular location ER
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID 5K6W,
Predicted Structure ID SPKB12397.cif
Physicochemical Information
Molecular weight 240305.6195
Aliphatic index 81.85134519
Isoelectric point 6.756420082
Charge (pH=7) -13.13535951
Topological polar surface area 98474.21
Aromaticity 0.081167351
Average rotatable bonds 0.455996352
Number of hydrogen bond donors 1000
Number of hydrogen bond acceptors 1000
X logP energy -1055.30977
Hydropathy 
Literature Information
