SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB11465

Signal sequence   MDYAKRIGQVGALAVVLGVGAAVTTHAIGSA

Length  31

Organism  Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

UniProt ID  P9WKQ1,

Motif  1..31



Activity Information


Pathway  NA

Natural/Artificial  Natural

Subcellular location  Cell membrane

Secretion efficiency  NA

Type  NA



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB11465.cif

Structure  SPKB11465.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2997.50594

Aliphatic index  119.6774194

Isoelectric point  9.299751799

Charge (pH=7)   1.088191115

Topological polar surface area  1214.23

Aromaticity  0.032258065

Average rotatable bonds  3.129032258

Number of hydrogen bond donors  43

Number of hydrogen bond acceptors  42

X logP energy  -12.74343

Hydropathy 



Literature Information


Title  Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages.

DOI  10.1111/mmi.13073,

Publication Year  2015

PubMed ID  26036301,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.