SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB11269

Signal sequence   MKVSAALLCLLLMAATFSPQGLA

Length  23

Organism  Homo sapiens (Human)

UniProt ID  P80075,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB11269.cif

Structure  SPKB11269.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2349.93374

Aliphatic index  136.0869565

Isoelectric point  8.545189979

Charge (pH=7)   0.93571455

Topological polar surface area  824.53

Aromaticity  0.043478261

Average rotatable bonds  3.304347826

Number of hydrogen bond donors  29

Number of hydrogen bond acceptors  32

X logP energy  -5.3278

Hydropathy 



Literature Information


Title  Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptors.

DOI  10.1021/bi0009340,

Publication Year  2000

PubMed ID  11087354,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.