SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB10007

Signal sequence   MTPHRLLPPLLLLLALLLAASPGGALA

Length  27

Organism  Homo sapiens (Human)

UniProt ID  P24592,

Motif  1..27



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB10007.cif

Structure  SPKB10007.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2733.43774

Aliphatic index  177.4074074

Isoelectric point  10.5517587

Charge (pH=7)   1.088890079

Topological polar surface area  915.8

Aromaticity  0

Average rotatable bonds  3.037037037

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  33

X logP energy  -2.74743

Hydropathy 



Literature Information


Title  Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia.

DOI  ,

Publication Year  1990

PubMed ID  1697583,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.