SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB09530

Signal sequence   MQHKRSRAMASPRSPFLFVLLALAVGGTANA

Length  31

Organism  Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

UniProt ID  P14789,

Motif  1..31



Activity Information


Pathway  NA

Natural/Artificial  Natural

Subcellular location  Extracellular environment

Secretion efficiency  NA

Type  NA



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB09530.cif

Structure  SPKB09530.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3298.91834

Aliphatic index  88.38709677

Isoelectric point  12.80742811

Charge (pH=7)   4.088588423

Topological polar surface area  1326.24

Aromaticity  0.064516129

Average rotatable bonds  3.419354839

Number of hydrogen bond donors  47

Number of hydrogen bond acceptors  45

X logP energy  -13.79189

Hydropathy 



Literature Information


Title  A substitution at His-120 in the LasA protease of Pseudomonas aeruginosa blocks enzymatic activity without affecting propeptide processing or extracellular secretion.

DOI  10.1128/jb.178.22.6608-6617.1996,

Publication Year  1996

PubMed ID  8932318,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.