SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB08611

Signal sequence   MAKDSQKNLNVSNNNNVQCTMGRSSQNINKSDSKGKIKRCTYAYKILLCTIFIWICQCFYNKSYYVYKKDGRRNKGKKILGIRINKSLAEMDHTKYHPEYYDEVQENYDPYYGVNQYSDECESYKSEDDDSEEEYYNSTPRVTVLEPQTENSEDEENYEKTIVDELNELPNDKKALILSYIRNGNDNNMQLLPYANNNKQNTQENISRNKEFFRHFVDFIKGYKLFDSPVLNALLPFIFIAFVYCTITMLVGNVRYIIALYILAKILKMHYDYKHKENNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKKSKKN

Length  100

Organism  Plasmodium falciparum (isolate 3D7)

UniProt ID  O97336,

Motif  1..NA



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  Host cytoplasm

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB08611.cif

Structure  SPKB08611.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  37389.41774

Aliphatic index  65.17350158

Isoelectric point  8.217206161

Charge (pH=7)   3.033135033

Topological polar surface area  16514.98

Aromaticity  0.113564669

Average rotatable bonds  3.154574132

Number of hydrogen bond donors  551

Number of hydrogen bond acceptors  544

X logP energy  -293.2122

Hydropathy 



Literature Information


Title  Deletion of the Plasmodium falciparum exported protein PTP7 leads to Maurer's clefts vesiculation, host cell remodeling defects, and loss of surface presentation of EMP1.

DOI  10.1371/journal.ppat.1009882,

Publication Year  2022

PubMed ID  35930605,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.