SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB08352

Signal sequence   MMLNKKVVALCTLTLHLFCIFLCLG

Length  25

Organism  Plasmodium falciparum

UniProt ID  O61142,

Motif  1..25



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  Vacuole

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  8POL,

Predicted Structure ID  SPKB08352.cif

Structure  SPKB08352.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2825.64444

Aliphatic index  152

Isoelectric point  8.52444823

Charge (pH=7)   1.902379175

Topological polar surface area  925.99

Aromaticity  0.08

Average rotatable bonds  3.76

Number of hydrogen bond donors  35

Number of hydrogen bond acceptors  37

X logP energy  -1.9926

Hydropathy 



Literature Information


Title  Maturation and specificity of Plasmodium falciparum subtilisin-like protease-1, a malaria merozoite subtilisin-like serine protease.

DOI  10.1074/jbc.275.1.631,

Publication Year  2000

PubMed ID  10617661,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.