General Information
SPKB ID SPKB07939
Signal sequence MHYLAVALPLLTLALA
Length 16
Organism Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
UniProt ID J9VS02,
Motif 1..16
Activity Information
Pathway SRP-dependent
Natural/Artificial Natural
Subcellular location ER
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID NA,
Predicted Structure ID SPKB07939.cif
Physicochemical Information
Molecular weight 1710.15094
Aliphatic index 189.375
Isoelectric point 7.542349207
Charge (pH=7) 0.088042976
Topological polar surface area 560.17
Aromaticity 0.0625
Average rotatable bonds 3.1875
Number of hydrogen bond donors 19
Number of hydrogen bond acceptors 21
X logP energy 0.2367
Hydropathy 
Literature Information
Title Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery.
DOI 10.1021/acs.jmedchem.0c02177,
Publication Year 2021
PubMed ID 34006103,
Patent ID NA,
