SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB07144

Signal sequence   MLFQPTLCAALGLAALIVQGGEA

Length  23

Organism  Yarrowia lipolytica JMY2101

UniProt ID  NA,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  Extracellular environment

Secretion efficiency  alpha-amylase yield: 1.86(U/mL)

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB07144.cif

Structure  SPKB07144.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2287.76064

Aliphatic index  136.0869565

Isoelectric point  3.849962145

Charge (pH=7)   -1.062215294

Topological polar surface area  838.44

Aromaticity  0.043478261

Average rotatable bonds  3.173913043

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  30

X logP energy  -5.8014

Hydropathy 



Literature Information


Title  Robust signal peptides for protein secretion in Yarrowia lipolytica: identification and characterization of novel secretory tags

DOI  10.1007/s00253-018-8966-9,

Publication Year  2018

PubMed ID  29704042,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.