SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB07142

Signal sequence   MKLSTILFTACATLAAA

Length  17

Organism  Yarrowia lipolytica JMY2101

UniProt ID  NA,

Motif  1..17



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  Extracellular environment

Secretion efficiency  alpha-amylase yield: 4.17(U/mL)

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB07142.cif

Structure  SPKB07142.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1726.12244

Aliphatic index  121.1764706

Isoelectric point  8.545189979

Charge (pH=7)   0.93571455

Topological polar surface area  635.86

Aromaticity  0.058823529

Average rotatable bonds  3.235294118

Number of hydrogen bond donors  24

Number of hydrogen bond acceptors  25

X logP energy  -5.3717

Hydropathy 



Literature Information


Title  Robust signal peptides for protein secretion in Yarrowia lipolytica: identification and characterization of novel secretory tags

DOI  10.1007/s00253-018-8966-9,

Publication Year  2018

PubMed ID  29704042,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.