SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB07141

Signal sequence   MKFSAVSIAAALASLVAA

Length  18

Organism  Yarrowia lipolytica JMY2101

UniProt ID  NA,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  Extracellular environment

Secretion efficiency  alpha-amylase yield: 4.35(U/mL)

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB07141.cif

Structure  SPKB07141.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1721.08814

Aliphatic index  136.1111111

Isoelectric point  9.700002532

Charge (pH=7)   0.997689266

Topological polar surface area  644.73

Aromaticity  0.055555556

Average rotatable bonds  3.055555556

Number of hydrogen bond donors  23

Number of hydrogen bond acceptors  24

X logP energy  -5.6688

Hydropathy 



Literature Information


Title  Robust signal peptides for protein secretion in Yarrowia lipolytica: identification and characterization of novel secretory tags

DOI  10.1007/s00253-018-8966-9,

Publication Year  2018

PubMed ID  29704042,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.