SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06556

Signal sequence   MKKWMITIAMLILAGIALFVFISPLKS

Length  27

Organism  Bacillus subtilis TEB1030

UniProt ID  Q45606,

Motif  1..27



Activity Information


Pathway  Sec

Natural/Artificial  Artificial

Subcellular location  Extracellular environment

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06556.cif

Structure  SPKB06556.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3036.91544

Aliphatic index  151.8518519

Isoelectric point  11.10307074

Charge (pH=7)   2.997099198

Topological polar surface area  965.67

Aromaticity  0.111111111

Average rotatable bonds  3.740740741

Number of hydrogen bond donors  34

Number of hydrogen bond acceptors  37

X logP energy  0.4924

Hydropathy 



Literature Information


Title  Systematic screening of all signal peptides from Bacillus subtilis: A powerful strategy in optimizing heterologous protein secretion in gram-positive bacteria

DOI  10.1016/j.jmb.2006.07.034,

Publication Year  2006

PubMed ID  16930615,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.