SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06520

Signal sequence   MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAA

Length  35

Organism  Bacillus subtilis TEB1030

UniProt ID  NA,

Motif  1..35



Activity Information


Pathway  Sec

Natural/Artificial  Artificial

Subcellular location  Extracellular environment

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06520.cif

Structure  SPKB06520.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3818.60934

Aliphatic index  108.8571429

Isoelectric point  11.07952226

Charge (pH=7)   2.998871009

Topological polar surface area  1480.63

Aromaticity  0.085714286

Average rotatable bonds  3.8

Number of hydrogen bond donors  52

Number of hydrogen bond acceptors  53

X logP energy  -12.89023

Hydropathy 



Literature Information


Title  Systematic screening of all signal peptides from Bacillus subtilis: A powerful strategy in optimizing heterologous protein secretion in gram-positive bacteria

DOI  10.1016/j.jmb.2006.07.034,

Publication Year  2006

PubMed ID  16930615,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.