SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06405

Signal sequence   MKTTLKMTALAALSAFVLAGC

Length  21

Organism  Haemophilus influenzae

UniProt ID  NA,

Motif  1..21



Activity Information


Pathway  Sec

Natural/Artificial  Natural

Subcellular location  Cell membrane

Secretion efficiency  NA

Type  Sec/SPII



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06405.cif

Structure  SPKB06405.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2141.67364

Aliphatic index  111.9047619

Isoelectric point  9.676237541

Charge (pH=7)   1.935419516

Topological polar surface area  778.28

Aromaticity  0.047619048

Average rotatable bonds  3.380952381

Number of hydrogen bond donors  29

Number of hydrogen bond acceptors  31

X logP energy  -6.263

Hydropathy 



Literature Information


Title  Lipoprotein Signal Peptide as Adjuvants: Leveraging Lipobox-Driven TLR2 Activation in Modern Vaccine Design

DOI  10.3390/vaccines13010036,

Publication Year  2025

PubMed ID  39852815,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.