SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06404

Signal sequence   MWATLPLLCAGAWLLGVPVCGA

Length  22

Organism  Homo sapiens (Human)

UniProt ID  NA,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6CZK,

Predicted Structure ID  SPKB06404.cif

Structure  SPKB06404.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2242.78344

Aliphatic index  133.1818182

Isoelectric point  5.826007312

Charge (pH=7)   -0.125965132

Topological polar surface area  708.65

Aromaticity  0.090909091

Average rotatable bonds  2.863636364

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  27

X logP energy  -1.4507

Hydropathy 



Literature Information


Title  Signal Peptides and Their Fragments in Post-Translation: Novel Insights of Signal Peptides

DOI  10.3390/ijms252413534,

Publication Year  2024

PubMed ID  39769297,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.