SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06401

Signal sequence   MMRTLILAVLLVYFCATVHC

Length  20

Organism  Artificial

UniProt ID  NA,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06401.cif

Structure  SPKB06401.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2297.92184

Aliphatic index  151

Isoelectric point  8.234443783

Charge (pH=7)   0.964090233

Topological polar surface area  767.49

Aromaticity  0.1

Average rotatable bonds  3.6

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  30

X logP energy  -1.60473

Hydropathy 



Literature Information


Title  Construction of an Integration Vector with a Chimeric Signal Peptide for the Expression of Monoclonal Antibodies in Mammalian Cells

DOI  10.3390/cimb46120868,

Publication Year  2024

PubMed ID  39727996,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.