General Information
SPKB ID SPKB06386
Signal sequence MALWMRLLPLLALALWGPDPAAAIF
Length 25
Organism Homo sapiens (Human)
UniProt ID NA,
Motif 1..25
Activity Information
Pathway SRP-dependent
Natural/Artificial Natural
Subcellular location ER
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID NA,
Predicted Structure ID SPKB06386.cif
Physicochemical Information
Molecular weight 2751.42954
Aliphatic index 148.8
Isoelectric point 6.338718596
Charge (pH=7) -0.001572528
Topological polar surface area 866.13
Aromaticity 0.12
Average rotatable bonds 3.2
Number of hydrogen bond donors 29
Number of hydrogen bond acceptors 30
X logP energy 1.60657
Hydropathy 
Literature Information
Title Pathogenic signal peptide variants in the human genome
Publication Year 2023
PubMed ID 37859801,
Patent ID NA,
