SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06381

Signal sequence   MRKKTLLLLAVLVVVLPSTSSS

Length  22

Organism  Artificial

UniProt ID  NA,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06381.cif

Structure  SPKB06381.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2355.94884

Aliphatic index  163.6363636

Isoelectric point  11.82305527

Charge (pH=7)   2.99739092

Topological polar surface area  900.95

Aromaticity  0

Average rotatable bonds  3.590909091

Number of hydrogen bond donors  33

Number of hydrogen bond acceptors  33

X logP energy  -6.98903

Hydropathy 



Literature Information


Title  Protein-Specific Signal Peptides for Mammalian Vector Engineering

DOI  10.1021/acssynbio.3c00157,

Publication Year  2023

PubMed ID  37487508,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.