SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06380

Signal sequence   MRKKTVLLVVLALLLAPIGASG

Length  22

Organism  Artificial

UniProt ID  NA,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06380.cif

Structure  SPKB06380.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2263.89734

Aliphatic index  177.2727273

Isoelectric point  11.82305527

Charge (pH=7)   2.99739092

Topological polar surface area  820.03

Aromaticity  0

Average rotatable bonds  3.454545455

Number of hydrogen bond donors  29

Number of hydrogen bond acceptors  29

X logP energy  -3.65403

Hydropathy 



Literature Information


Title  Protein-Specific Signal Peptides for Mammalian Vector Engineering

DOI  10.1021/acssynbio.3c00157,

Publication Year  2023

PubMed ID  37487508,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.