SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06370

Signal sequence   MDMRVPAQLLGLLLLWLSGARC

Length  22

Organism  Cricetulus cricetus

UniProt ID  NA,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  8JBV,

Predicted Structure ID  SPKB06370.cif

Structure  SPKB06370.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2457.05144

Aliphatic index  146.3636364

Isoelectric point  8.54983383

Charge (pH=7)   0.936449445

Topological polar surface area  905.84

Aromaticity  0.045454545

Average rotatable bonds  3.636363636

Number of hydrogen bond donors  33

Number of hydrogen bond acceptors  31

X logP energy  -4.21436

Hydropathy 



Literature Information


Title  Protein-Specific Signal Peptides for Mammalian Vector Engineering

DOI  10.1021/acssynbio.3c00157,

Publication Year  2023

PubMed ID  37487508,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.