SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06369

Signal sequence   MKLPVRLLVLMFWIPASSS

Length  19

Organism  Cricetulus cricetus

UniProt ID  NA,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  5B6F,

Predicted Structure ID  SPKB06369.cif

Structure  SPKB06369.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2188.76084

Aliphatic index  138.4210526

Isoelectric point  11.65177567

Charge (pH=7)   1.997685954

Topological polar surface area  733.94

Aromaticity  0.105263158

Average rotatable bonds  3.578947368

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  27

X logP energy  -1.45843

Hydropathy 



Literature Information


Title  Protein-Specific Signal Peptides for Mammalian Vector Engineering

DOI  10.1021/acssynbio.3c00157,

Publication Year  2023

PubMed ID  37487508,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.