SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06365

Signal sequence   MKWVTFISLLFLFSSAYS

Length  18

Organism  Cricetulus cricetus

UniProt ID  NA,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  4BKE,

Predicted Structure ID  SPKB06365.cif

Structure  SPKB06365.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2140.56784

Aliphatic index  108.3333333

Isoelectric point  9.298300651

Charge (pH=7)   0.996838851

Topological polar surface area  721.21

Aromaticity  0.277777778

Average rotatable bonds  3.666666667

Number of hydrogen bond donors  27

Number of hydrogen bond acceptors  27

X logP energy  -1.8673

Hydropathy 



Literature Information


Title  Protein-Specific Signal Peptides for Mammalian Vector Engineering

DOI  10.1021/acssynbio.3c00157,

Publication Year  2023

PubMed ID  37487508,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.