SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06347

Signal sequence   MQELRGILLCLLLAAAVPTTP

Length  21

Organism  Homo sapiens (Human)

UniProt ID  NA,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06347.cif

Structure  SPKB06347.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2223.76064

Aliphatic index  158.0952381

Isoelectric point  6.232433001

Charge (pH=7)   -0.062218605

Topological polar surface area  810.49

Aromaticity  0

Average rotatable bonds  3.333333333

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  29

X logP energy  -4.38543

Hydropathy 



Literature Information


Title  Protein-Specific Signal Peptides for Mammalian Vector Engineering

DOI  10.1021/acssynbio.3c00157,

Publication Year  2023

PubMed ID  37487508,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.