SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06345

Signal sequence   MLLGPGHTLSAPALALAVTLTLLVRSASP

Length  29

Organism  Homo sapiens (Human)

UniProt ID  NA,

Motif  1..29



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06345.cif

Structure  SPKB06345.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2871.47464

Aliphatic index  144.8275862

Isoelectric point  10.5517587

Charge (pH=7)   1.088890079

Topological polar surface area  1063.71

Aromaticity  0

Average rotatable bonds  3

Number of hydrogen bond donors  37

Number of hydrogen bond acceptors  39

X logP energy  -9.36413

Hydropathy 



Literature Information


Title  Protein-Specific Signal Peptides for Mammalian Vector Engineering

DOI  10.1021/acssynbio.3c00157,

Publication Year  2023

PubMed ID  37487508,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.