General Information
SPKB ID SPKB06341
Signal sequence MVVMAPRTLFLLLSGALTLTETWA
Length 24
Organism Homo sapiens (Human)
UniProt ID NA,
Motif 1..24
Activity Information
Pathway SRP-dependent
Natural/Artificial Natural
Subcellular location ER
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID NA,
Predicted Structure ID SPKB06341.cif
Physicochemical Information
Molecular weight 2635.21844
Aliphatic index 134.1666667
Isoelectric point 6.410149741
Charge (pH=7) -0.000243889
Topological polar surface area 939.97
Aromaticity 0.083333333
Average rotatable bonds 3.416666667
Number of hydrogen bond donors 34
Number of hydrogen bond acceptors 34
X logP energy -4.54893
Hydropathy 
Literature Information
Title HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses
DOI 10.1038/s41590-023-01523-z,
Publication Year 2023
PubMed ID 37264229,
Patent ID NA,
