General Information
SPKB ID SPKB06338
Signal sequence MAVMPPRTLLLLLSGALALTQTWA
Length 24
Organism Homo sapiens (Human)
UniProt ID NA,
Motif 1..24
Activity Information
Pathway SRP-dependent
Natural/Artificial Natural
Subcellular location ER
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID NA,
Predicted Structure ID SPKB06338.cif
Physicochemical Information
Molecular weight 2568.17424
Aliphatic index 142.5
Isoelectric point 10.55000222
Charge (pH=7) 0.997980988
Topological polar surface area 916.74
Aromaticity 0.041666667
Average rotatable bonds 3.291666667
Number of hydrogen bond donors 32
Number of hydrogen bond acceptors 33
X logP energy -4.85553
Hydropathy 
Literature Information
Title HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses
DOI 10.1038/s41590-023-01523-z,
Publication Year 2023
PubMed ID 37264229,
Patent ID NA,
