General Information
SPKB ID SPKB06337
Signal sequence MAVMAPRTVLLLLSGALALTQTWA
Length 24
Organism Homo sapiens (Human)
UniProt ID NA,
Motif 1..24
Activity Information
Pathway SRP-dependent
Natural/Artificial Natural
Subcellular location ER
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID NA,
Predicted Structure ID SPKB06337.cif
Physicochemical Information
Molecular weight 2528.10954
Aliphatic index 142.5
Isoelectric point 10.55000222
Charge (pH=7) 0.997980988
Topological polar surface area 925.53
Aromaticity 0.041666667
Average rotatable bonds 3.291666667
Number of hydrogen bond donors 33
Number of hydrogen bond acceptors 33
X logP energy -5.73193
Hydropathy 
Literature Information
Title HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses
DOI 10.1038/s41590-023-01523-z,
Publication Year 2023
PubMed ID 37264229,
Patent ID NA,
