SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06334

Signal sequence   MKKKKKILTLVFIFVISILTAAPTNAHAA

Length  29

Organism  Pediococcus pentosaceus

UniProt ID  NA,

Motif  1..29



Activity Information


Pathway  NA

Natural/Artificial  Artificial

Subcellular location  Extracellular environment

Secretion efficiency  NA

Type  NA



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06334.cif

Structure  SPKB06334.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3168.96164

Aliphatic index  131.3793103

Isoelectric point  11.40292058

Charge (pH=7)   5.087418221

Topological polar surface area  1152.12

Aromaticity  0.068965517

Average rotatable bonds  3.689655172

Number of hydrogen bond donors  40

Number of hydrogen bond acceptors  42

X logP energy  -5.9275

Hydropathy 



Literature Information


Title  Optimization of Signal Peptide via Site-Directed Mutagenesis for Enhanced Secretion of Heterologous Proteins in Lactococcus lactis

DOI  10.3390/ijms231710044,

Publication Year  2022

PubMed ID  36077441,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.