SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06332

Signal sequence   MKKILTLVFIFVISILTAATNAHAA

Length  25

Organism  Pediococcus pentosaceus

UniProt ID  NA,

Motif  1..25



Activity Information


Pathway  NA

Natural/Artificial  Artificial

Subcellular location  Extracellular environment

Secretion efficiency  NA

Type  NA



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06332.cif

Structure  SPKB06332.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2687.32264

Aliphatic index  152.4

Isoelectric point  10.80542203

Charge (pH=7)   2.088303323

Topological polar surface area  966.45

Aromaticity  0.08

Average rotatable bonds  3.52

Number of hydrogen bond donors  34

Number of hydrogen bond acceptors  35

X logP energy  -4.7599

Hydropathy 



Literature Information


Title  Optimization of Signal Peptide via Site-Directed Mutagenesis for Enhanced Secretion of Heterologous Proteins in Lactococcus lactis

DOI  10.3390/ijms231710044,

Publication Year  2022

PubMed ID  36077441,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.