General Information
SPKB ID SPKB06326
Signal sequence MKKKIISAILMSTVILSAAAPLSGVYA
Length 27
Organism Lactococcus lactis subsp. cremoris MG1363
UniProt ID P22865,
Motif 1..27
Activity Information
Pathway Sec
Natural/Artificial Artificial
Subcellular location Extracellular environment
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID NA,
Predicted Structure ID SPKB06326.cif
Physicochemical Information
Molecular weight 2777.46024
Aliphatic index 141.1111111
Isoelectric point 10.64292272
Charge (pH=7) 2.996248784
Topological polar surface area 1010.57
Aromaticity 0.037037037
Average rotatable bonds 3.444444444
Number of hydrogen bond donors 36
Number of hydrogen bond acceptors 39
X logP energy -6.9336
Hydropathy 
Literature Information
Title Optimization of Signal Peptide via Site-Directed Mutagenesis for Enhanced Secretion of Heterologous Proteins in Lactococcus lactis
Publication Year 2022
PubMed ID 36077441,
Patent ID NA,
