General Information
SPKB ID SPKB06319
Signal sequence MKKLLFAIPLVVPFYAMAFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSL
Length 70
Organism Escherichia coli
UniProt ID NA,
Motif 1..70
Activity Information
Pathway NA
Natural/Artificial Artificial
Subcellular location Periplasmic space
Secretion efficiency NA
Type NA
Structure Information
PDB ID 1A22,
Predicted Structure ID SPKB06319.cif
Physicochemical Information
Molecular weight 8279.71374
Aliphatic index 90.71428571
Isoelectric point 8.945758565
Charge (pH=7) 1.183204214
Topological polar surface area 3093.35
Aromaticity 0.157142857
Average rotatable bonds 3.785714286
Number of hydrogen bond donors 103
Number of hydrogen bond acceptors 106
X logP energy -17.46769
Hydropathy 
Literature Information
Title In silico and in vitro analysis of a rational mutation in gIII signal peptide and its effects on periplasmic expression of rhGH in E. coli
DOI 10.1007/s00203-022-03193-1,
Publication Year 2022
PubMed ID 36001178,
Patent ID NA,
