General Information
SPKB ID SPKB06318
Signal sequence MKKLLFAIPLVVPFYSHSFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSL
Length 70
Organism Escherichia coli
UniProt ID NA,
Motif 1..70
Activity Information
Pathway NA
Natural/Artificial Artificial
Subcellular location Periplasmic space
Secretion efficiency NA
Type NA
Structure Information
PDB ID 1A22,
Predicted Structure ID SPKB06318.cif
Physicochemical Information
Molecular weight 8317.66104
Aliphatic index 87.85714286
Isoelectric point 8.948707904
Charge (pH=7) 1.274113305
Topological polar surface area 3162.49
Aromaticity 0.157142857
Average rotatable bonds 3.8
Number of hydrogen bond donors 106
Number of hydrogen bond acceptors 108
X logP energy -20.31019
Hydropathy 
Literature Information
Title In silico and in vitro analysis of a rational mutation in gIII signal peptide and its effects on periplasmic expression of rhGH in E. coli
DOI 10.1007/s00203-022-03193-1,
Publication Year 2022
PubMed ID 36001178,
Patent ID NA,
