SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06310

Signal sequence   MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVASA

Length  44

Organism  Bacillus subtilis

UniProt ID  NA,

Motif  1..44



Activity Information


Pathway  NA

Natural/Artificial  Artificial

Subcellular location  Extracellular environment

Secretion efficiency  NA

Type  NA



Structure Information


PDB ID  7PKX,

Predicted Structure ID  SPKB06310.cif

Structure  SPKB06310.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  4473.19124

Aliphatic index  95.68181818

Isoelectric point  9.44043693

Charge (pH=7)   1.09244488

Topological polar surface area  1839.44

Aromaticity  0.022727273

Average rotatable bonds  3.409090909

Number of hydrogen bond donors  63

Number of hydrogen bond acceptors  62

X logP energy  -18.84426

Hydropathy 



Literature Information


Title  Enhanced extracellular recombinant keratinase activity in Bacillus subtilis SCK6 through signal peptide optimization and site-directed mutagenesis

DOI  10.1039/c9ra07866e,

Publication Year  2019

PubMed ID  35529123,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.