SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06307

Signal sequence   MLLLLLLLGLRLQLSLG

Length  17

Organism  Homo sapiens (Human)

UniProt ID  NA,

Motif  1..17



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06307.cif

Structure  SPKB06307.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1879.46144

Aliphatic index  252.3529412

Isoelectric point  10.55000222

Charge (pH=7)   0.997980988

Topological polar surface area  654.14

Aromaticity  0

Average rotatable bonds  3.882352941

Number of hydrogen bond donors  23

Number of hydrogen bond acceptors  22

X logP energy  0.19917

Hydropathy 



Literature Information


Title  Signal Sequence-Dependent Orientation of Signal Peptide Fragments to Exosomes

DOI  10.3390/ijms23063137,

Publication Year  2022

PubMed ID  35328557,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.