SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06279

Signal sequence   RGLPALLLLLFLGPWPAAV

Length  19

Organism  Homo sapiens (Human)

UniProt ID  NA,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06279.cif

Structure  SPKB06279.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2017.53124

Aliphatic index  174.7368421

Isoelectric point  10.55000222

Charge (pH=7)   0.997980988

Topological polar surface area  638.44

Aromaticity  0.105263158

Average rotatable bonds  3

Number of hydrogen bond donors  21

Number of hydrogen bond acceptors  21

X logP energy  1.17447

Hydropathy 



Literature Information


Title  Cross-presentation of a TAP-independent signal peptide induces CD8 T immunity to escaped cancers but necessitates anchor replacement

DOI  10.1007/s00262-021-02984-7,

Publication Year  2022

PubMed ID  34142235,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.