SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06277

Signal sequence   FLGPWPAAS

Length  9

Organism  Homo sapiens (Human)

UniProt ID  NA,

Motif  1..9



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06277.cif

Structure  SPKB06277.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  945.08554

Aliphatic index  65.55555556

Isoelectric point  6.099999998

Charge (pH=7)   -0.002015701

Topological polar surface area  314.56

Aromaticity  0.222222222

Average rotatable bonds  2.444444444

Number of hydrogen bond donors  10

Number of hydrogen bond acceptors  11

X logP energy  -1.0346

Hydropathy 



Literature Information


Title  Cross-presentation of a TAP-independent signal peptide induces CD8 T immunity to escaped cancers but necessitates anchor replacement

DOI  10.1007/s00262-021-02984-7,

Publication Year  2022

PubMed ID  34142235,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.