SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06268

Signal sequence   MKYLLPTAAAGLLLLAAQPTMA

Length  22

Organism  Escherichia coli

UniProt ID  NA,

Motif  1..22



Activity Information


Pathway  NA

Natural/Artificial  Artificial

Subcellular location  Extracellular environment

Secretion efficiency  NA

Type  NA



Structure Information


PDB ID  8H83,

Predicted Structure ID  SPKB06268.cif

Structure  SPKB06268.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2258.80594

Aliphatic index  133.6363636

Isoelectric point  9.298300651

Charge (pH=7)   0.996838851

Topological polar surface area  786.64

Aromaticity  0.045454545

Average rotatable bonds  3.181818182

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  30

X logP energy  -3.7705

Hydropathy 



Literature Information


Title  Enhanced Extracellular Production of IsPETase in Escherichia coli via Engineering of the pelB Signal Peptide

DOI  10.1021/acs.jafc.0c07469,

Publication Year  2021

PubMed ID  33576230,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.