SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06262

Signal sequence   MKWVTFISLLFLFSAYS

Length  17

Organism  Homo sapiens (Human)

UniProt ID  NA,

Motif  1..17



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06262.cif

Structure  SPKB06262.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2053.48964

Aliphatic index  114.7058824

Isoelectric point  9.298300651

Charge (pH=7)   0.996838851

Topological polar surface area  671.88

Aromaticity  0.294117647

Average rotatable bonds  3.705882353

Number of hydrogen bond donors  25

Number of hydrogen bond acceptors  25

X logP energy  -0.3444

Hydropathy 



Literature Information


Title  Comparison of Different Signal Peptides for the Efficient Secretion of the Sweet-Tasting Plant Protein Brazzein in Pichia pastoris

DOI  10.3390/life11010046,

Publication Year  2021

PubMed ID  33450886,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.