SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06259

Signal sequence   MNLYLITLLFASLCSA

Length  16

Organism  Komagataella phaffii

UniProt ID  NA,

Motif  1..16



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB06259.cif

Structure  SPKB06259.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1773.17854

Aliphatic index  158.75

Isoelectric point  5.919503212

Charge (pH=7)   -0.064840831

Topological polar surface area  623.83

Aromaticity  0.125

Average rotatable bonds  3.5

Number of hydrogen bond donors  23

Number of hydrogen bond acceptors  24

X logP energy  -2.8986

Hydropathy 



Literature Information


Title  Comparison of Different Signal Peptides for the Efficient Secretion of the Sweet-Tasting Plant Protein Brazzein in Pichia pastoris

DOI  10.3390/life11010046,

Publication Year  2021

PubMed ID  33450886,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.