SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB06258

Signal sequence   MVAWWSLFLYGLQVAAPALA

Length  20

Organism  Aspergillus niger

UniProt ID  NA,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6XSJ,

Predicted Structure ID  SPKB06258.cif

Structure  SPKB06258.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2207.66114

Aliphatic index  132

Isoelectric point  6.093198033

Charge (pH=7)   -0.002866115

Topological polar surface area  722.56

Aromaticity  0.2

Average rotatable bonds  3.15

Number of hydrogen bond donors  25

Number of hydrogen bond acceptors  25

X logP energy  -0.0071

Hydropathy 



Literature Information


Title  Comparison of Different Signal Peptides for the Efficient Secretion of the Sweet-Tasting Plant Protein Brazzein in Pichia pastoris

DOI  10.3390/life11010046,

Publication Year  2021

PubMed ID  33450886,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.