General Information
SPKB ID SPKB06256
Signal sequence MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKARREVEDLQVRDVELAGAPGEGGLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN
Length 110
Organism Homo sapiens (Human)
UniProt ID NA,
Motif 1..110
Activity Information
Pathway SRP-dependent
Natural/Artificial Artificial
Subcellular location ER
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID 1APH,
Predicted Structure ID SPKB06256.cif
Physicochemical Information
Molecular weight 12121.09374
Aliphatic index 106.4545455
Isoelectric point 4.761780919
Charge (pH=7) -4.17874185
Topological polar surface area 4732.57
Aromaticity 0.081818182
Average rotatable bonds 3.572727273
Number of hydrogen bond donors 166
Number of hydrogen bond acceptors 160
X logP energy -37.60138
Hydropathy 
Literature Information
Title Improved secretion of recombinant human IL-25 in HEK293 cells using a signal peptide-pro-peptide domain derived from Trypsin-1
DOI 10.1007/s10529-020-03072-z,
Publication Year 2021
PubMed ID 33415569,
Patent ID NA,
